I. Neurotoxic mechanisms of CT
In relation to the neurotoxic mechanisms and physiological
roles of C-terminal fragment of amyloid precursor protein
(CT), it is being intensively investigated which proteins
are involved in death signal pathway, interacting with CT
and which genes are induced after translocalization of CT
into the nucleus.
II. Pathogenic roles of a-synuclein
Pathogenic roles of -synuclein in the onset of
neurodegenerative diseases such as AD and PD are recent hot
issues in worldwide neuroscience research field. It is also
one of the important themes of our Alzheimers Dementia
Research Center. Furthermore, the normal function of -
synuclein, which is unidentified yet, is being studied,
mainly in central nervous system and immune system.
III. Development of therapeutic drugs for AD
Inhibitors of -secretase which could suppress the
production of A and CT from amyloid precursor protein
and also vaccines against A and CT, which are deposited
in AD patient's brain are being developed as new and
fundamental therapeutic strategies for AD.

1980~1993 Assistant Professor, Dept. of Pharmacology,
Coll. of Med., Seoul Nat'l Univ.
1984~1986 Cornell Univ. Medical College, Visiting
Professor
1989~1990 Heidelberg University, Visiting Professor

1992~1993 Tokyo University, Visiting Professor
1993~ present, Professor, Dept. of Pharmacology, Coll.
of Med., Seoul Nat'l Univ.
1994, 1996 Imperial College, Visiting Professor
1995. 1~3 RIKEN Japan, Visiting Professor
1995~ Journal of Neurochemistry, Editor
1996~ Council member of Federation of Asian-Oceanian
Neuroscience Societies
1996~1998 President of Asian Pacific Society for
Neurochemistry
1997~ Journal of Molecular Neuroscience, Editor
1997~1999 Dean, Kangwon National University, College of
Medicine.
1998~ Journal of Neuroscience Research, Editor
1999~2000 President, Korean Brain Society
2000~ present, Director, Neuroscience Research Institute
Molecular Research Center Seoul Nat'l Univ.
2000~ present, Director, National Creative Research
Initiative Centre for Alzheimer's Dementia
2000~ present, President, Korean Society for Brain &
Neural Science
2002 President, Korean Society of Pharmacology
2001~ President of Federation of Asian-Oceanian
Neuroscience Societies
2002~ present, Chairman & Professor, Dept. of
Pharmacology, Coll. of Med., Seoul Nat'l Univ.
2002~ Neurochemical Research, Editor
2003~ present, President, The Korean Society for
Cognitive Science.

1991 Korean Science Excellence Award
1992 Yu Han Prize
1996 Kwang Hae Awards
1997 Korean Scientific Authorship Award
1997 Se Jong Prize
2001 One of Best Korean 20 Biomedical Researchers
2002 Government Medal for Science Development
2002 Yu Han GrandPrize